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Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 333-346 doi: 10.1007/s11684-020-0776-7

Abstract: Upon viral invasion, the innate immune system responds rapidly and plays a key role in activating theadaptive immune system.In the innate immune system, the interactions between pathogen-associated molecular patterns and hostMacrophages, dendritic cells, and natural killer cells are the principal innate immune components thatThis knowledge provides an enhanced understanding of the innate immune response to RNA viral infections

Keywords： innate immune viral infection intercellular signaling metabolic changes epigenetic changes

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Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3, Pages 260-267 doi: 10.15302/J-FASE-2016116

Abstract: The innate immune response is the first line of defense against viral invasion and pro-inflammatory chemokinesand cytokines have a critical function in the innate immune responses against virus infections.leukocytes into the CNS, enhancement of blood brain barrier permeability and activation of various immuneIn addition, recombinant RABV expressing cytokines and chemokines can induce elevated innate and adaptiveimmune responses which result in clearing an established wild-type RABV infection in the CNS.

Keywords： antiviral blood brain barrier chemokines and cytokines innate immunity rabies virus

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibitsthe activation of immune cells through the interaction with its ligand CD24 on tumor cells.

Keywords： innate immune checkpoint Siglec10 kidney renal clear cell carcinoma

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: In the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation ofthe innate immune player IRF7 in the p53-mutated TNBC cell line (upregulation by 16-fold) and

Keywords： p53 mutation triple-negative breast cancer decitabine DNMT1 IRF7 innate immune response

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Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance Review

Xiaojie Gan, Jian Gu, Zheng Ju, Ling Lu

Engineering 2022, Volume 10, Issue 3, Pages 44-56 doi: 10.1016/j.eng.2021.03.029

Abstract:

Organ transplant rejection (OTR) is a complex immune reaction involvingHowever, immunosuppressive agents negatively impact the immune system of the patients, causing them toTherefore, a thorough understanding of the mechanisms involved in immune tolerance and immune rejectionThis article reviews the role of immune cells in OTR and organ transplant tolerance (OTT), including

Keywords： Immune cells Innate immune cells Adaptive immune cells Organ transplant Immune tolerance

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Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 385-393 doi: 10.1007/s11684-010-0600-x

Abstract: primary response gene 88 (MyD88)-dependent or-independent signaling respectively, thereby modulating innateThese studies of TLRs in the innate immune system have implications for the prevention and treatment

Keywords： Toll-like receptors innate immunity infectious disease inflammation

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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1, Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: During natural infection, viral replication is initially controlled by innate immunity before adaptiveimmune responses (T cells and antibody-producing B cells) achieve viral clearance and host recovery.Recent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)in controlling influenza and linking innate and adaptive immune mechanisms, thus making them attractiveWe summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptive

Keywords： influenza innate T cells CD4⁺ and CD8⁺ T cells vaccination

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsnon-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related

Keywords： cancer immunotherapy immune checkpoint inhibitors immune-related adverse events review

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: NK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infectedIn addition to the innate direct “killer” functions, NK cell activity contributes to regulateinnate and adaptive immunity (helper or regulator).Under the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immuneresponses, leading to either immune activation or immune tolerance.

Keywords： natural killer cell phenotype immune activation immune tolerance liver diseases

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 816-819 doi: 10.1007/s11684-020-0823-4

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune

Keywords： molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H

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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 1-5 doi: 10.1007/s11684-014-0309-3

Abstract: instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immuneCytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immune

Keywords： hyperthermia HPV immune response virus tumor

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SARS-CoV-2 variants, immune escape, and countermeasures

Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 196-207 doi: 10.1007/s11684-021-0906-x

Abstract: Although many countries have promoted roll-out vaccination, the immune barrier has not yet been fully

Keywords： SARS-CoV-2 COVID-19 vaccine immune escape breakthrough prevention

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Multi-target combinatory strategy to overcome tumor immune escape

Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 208-215 doi: 10.1007/s11684-022-0922-5

Abstract: Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancerMany immune checkpoints were identified in the last decade since ipilimumab, which is the first immuneHowever, fewer people are benefitting from immune checkpoint inhibitor treatment in solid cancers.Along with the characterization of more immune checkpoints, the combinatory treatment of multi-immuneIn this work, the author focuses on the combination therapy of multiple immune checkpoints (does not

Keywords： immune checkpoints multi-target immune escape immune-related adverse events combination therapy